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Alzheimer's dementia
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Drug Name:


Generic Name and Formulations:
Donepezil HCl 5mg, 10mg, 23mg; tabs.

Eisai Pharmaceuticals

Therapeutic Use:

Indications for ARICEPT:

Alzheimer's dementia.


Tabs: Swallow whole with water. ODT: dissolve on tongue, follow with water. Mild-to-moderate: Initially 5mg daily at bedtime, may increase to max 10mg daily after 4–6 weeks; usual dose: 5mg or 10mg once daily. Moderate-to-severe: initially 5mg daily at bedtime, may increase to 10mg daily after 4–6 weeks; may further increase to max 23mg daily after 3 months; usual dose: 10mg or 23mg once daily.


Not established.


Cardiac conduction conditions. Peptic ulcer. Monitor for GI bleeding. Seizures. Asthma or COPD. GU obstruction. Body weight <55kg. Pregnancy (Cat.C). Nursing mothers.


Drugs that affect CYP2D6 and CYP3A4 may affect rate of elimination. Antagonizes anticholinergics. May potentiate succinylcholine-type muscle relaxants, other cholinesterase inhibitors, cholinergic agonists (eg, bethanecol). Concomitant NSAIDs may increase risk of GI bleed.

See Also:


Pharmacological Class:

Reversible acetylcholinesterase inhibitor (piperidine deriv).

Adverse Reactions:

Nausea, diarrhea, vomiting, insomnia, muscle cramps, fatigue, anorexia, weight loss (esp. using 23mg/day dose).

How Supplied:

Tabs 5mg, 10mg—30, 90, 1000; 23mg—30, 90; ODT—30

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