This site is intended for healthcare professionals

ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

ALOXI
Nausea
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

ALOXI Rx

Generic Name and Formulations:
Palonosetron (as HCl) 0.075mg/1.5mL, 0.25mg/5mL; IV inj; contains mannitol.

Company:
Eisai Pharmaceuticals

Therapeutic Use:

Indications for ALOXI:

Prevention of acute nausea and vomiting due to initial and repeat courses of moderately and highly emetogenic chemotherapy in adults. Prevention of delayed nausea and vomiting due to initial and repeat courses of moderately emetogenic chemotherapy in adults. Prevention of acute nausea and vomiting due to initial and repeat courses of emetogenic chemotherapy, including highly emetogenic cancer chemotherapy, in children 1 month–<17yrs. Prevention of post-op nausea and vomiting for up to 24hrs after surgery in adults.

Adult:

≥17yrs: give 30 mins prior to chemotherapy. 0.25mg IV as a single-dose over 30 secs. Post-op: give immediately before anesthesia induction. 0.075mg IV over 10 secs.

Children:

<1 month: not established. 1 month–<17yrs: give 30 mins prior to chemotherapy. 0.02mg/kg IV as a single-dose over 15 mins; max 1.5mg/dose.

Warnings/Precautions:

Pregnancy (Cat.B). Nursing mothers: not recommended.

Pharmacological Class:

Selective 5-HT3 receptor antagonist.

Adverse Reactions:

Headache, constipation, bradycardia, QT prolongation, diarrhea, dizziness, tachycardia, hypotension.

How Supplied:

Single-use vial (0.075mg/1.5mL)—5; (0.25mg/5mL)—1

Join MIMS Learning now to manage all your CPD and notes in one place!

By registering you agree with our Terms and Conditions and Privacy Policy.


Already a MIMS Learning member?

Sign In Now »
Red flag CPD modules
0.50 Credits
Red flags

Fever in adults - red flag symptomsExternal web site

Fever in adults can have potentially serious causes, ranging from sepsis to malignancy. Dr Pipin Singh...

0.50 Credits
Red flags

Bone pain - red flag symptomsExternal web site

In this article Dr Pipin Singh advises on how to identify red flags in patients presenting with bone...

0.50 Credits
Red flags

Pregnancy - red flag symptomsExternal web site

Dr Matthew West covers the red flags to look out for in pregnancy, including back pain, bleeding, headaches...

Font Awesome Icons
View more
Clinical review CPD modules
1.50 Credits
Clinical Review

Bronchiectasis: clinical reviewExternal web site

This article, updated in 2016 by Dr Anthony De Soyza, advises on causes, investigations and managing...

1.50 Credits
Clinical Review

Brugada syndrome: clinical reviewExternal web site

Dr Keith Barnard discusses the aetiology and symptoms of Brugada syndrome. Key learning points for GPs...

1.50 Credits
Clinical Review

Measles: clinical reviewExternal web site

Dr Kirsty Le Doare and Dr Nuria Martinez-Alier describe the signs and symptoms of measles and outline...

Font Awesome Icons
View more

is free, fast, and customized just for you!

Already a member?

Sign In Now »