Generic Name and Formulations:
Nifedipine 30mg, 60mg; ext-rel tabs.
Swallow whole. Initially 30mg once daily, titrate over 7–14 days; usual maintenance dose: 30–60mg once daily; max 90mg/day.
Aortic stenosis. Angina. Severe obstructive coronary artery disease. Heart failure. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.
Hypotension, angina and heart failure possible with β-blockers (esp. timolol). Potentiated by quinidine (monitor heart rate; adjust dose); diltiazem, verapamil, doxazosin, ketoconazole, itraconazole, fluconazole, cimetidine, quinupristin/dalfopristin, erythromycin, nefazodone, valproic acid, (reduce nifedipine dose); amprenavir, atazanavir, delavirine, fosamprenavir, indinavir, nelfinavir, ritonavir, grapefruit juice (avoid). Antagonized by rifampin, rifapentine, phenytoin, phenobarbitone, carbamazepine, St. John's Wort. Potentiates digoxin, tacrolimus (monitor). Antagonizes doxazosin. Hypotension possible with fentanyl. Monitor oral anticoagulants. Hyperglycemia with acarbose.
Calcium channel blocker (CCB) (dihydropyridine).
Headache, flushing/heat sensation, fatigue, dizziness, constipation, nausea, edema; rare: increased angina, acute MI.
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