This site is intended for healthcare professionals


Select the drug indication to add to your list

Bleeding disorders
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:


Generic Name and Formulations:
Antihemophilic Factor VIII (recombinant) 250 IU, 500 IU, 750 IU, 1000 IU, 2000 IU; per vial; PEGylated lyophilized pwd for IV inj after reconstitution; preservative-free.


Therapeutic Use:

Indications for ADYNOVATE:

In patients with Hemophilia A: for on-demand treatment and control of bleeding episodes, perioperative management, and routine prophylaxis to reduce the frequency of bleeding episodes.

Limitations Of use:

Not for treating von Willebrand disease.

Adults and Children:

Dosage Required (IU) = Body Weight (kg) × Desired Factor VIII Increase (IU/dL or % of Normal) × 0.5 (IU/kg per IU/dL). Infuse over ≤5 minutes (max infusion rate 10mL/min). Bleeding (Minor): obtain 20–40% FVIII increase; give every 12–24hrs until resolved; (Moderate): obtain 30–60% FVIII increase; give every 12–24hrs until resolved; (Major): obtain 60–100% FVIII increase; give every 8–24hrs until resolved. Perioperative (Minor surgery): obtain 60–100% FVIII increase; give 1hr before surgery; repeat after 24hrs if needed until bleeding resolved; (Major surgery): obtain 80–120% FVIII increase (pre- and post-op); give 1hr before surgery; repeat every 8–24hrs (6–24hrs if <12yrs) until adequate wound healing. Routine prophylaxis: ≥12yrs: give 40–50 IU/kg twice weekly; <12yrs: 55 IU/kg twice weekly; max 70 IU/kg. Adjust based on response.


Prior anaphylactic reaction to Advate. Mouse or hamster protein sensitivity.


Monitor for development of Factor VIII inhibitors. Immediately discontinue if hypersensitivity reactions occur. Pregnancy. Nursing mothers.

Pharmacological Class:

Clotting factor.

Adverse Reactions:

Headache, nausea, diarrhea, flushing; antibody formation.

Generic Availability:


How Supplied:

Single-dose vial—1 (w. diluent, Baxject II needleless transfer device)

Join MIMS Learning now to manage all your CPD and notes in one place!

By registering you agree with our Terms and Conditions and Privacy Policy.

Already a MIMS Learning member?

Sign In Now »
Red flag CPD modules
0.50 Credits
Red flags

Groin swelling - red flag symptomsExternal web site

This red flags article explains signs and symptoms of potentially serious pathology in patients presenting...

0.50 Credits
Red flags

Erectile dysfunction - red flag symptomsExternal web site

This article by Dr Tillmann Jacobi covers the possible red flag symptoms to consider when a patient...

0.50 Credits
Red flags

Headache - red flag symptomsExternal web site

Dr Suneeta Kochhar provides an overview of red flag symptoms in patients presenting with headaches...

Font Awesome Icons
View more
Clinical review CPD modules
1.50 Credits
Clinical Review

Basal cell carcinoma: clinical reviewExternal web site

In this article, Dr David Brass and Dr Neil Rajan discuss the risk factors for BCC, making the diagnosis...

1.50 Credits
Clinical Review

Cardiomyopathy: clinical reviewExternal web site

This article by Dr Rajiv Sankaranarayanan covers the diagnosis and management of cardiomyopathy. Key...

1.50 Credits
Clinical Review

Parkinson's disease: clinical reviewExternal web site

Dr Benjamin Simpson provides an in-depth overview of Parkinson’s disease, including information on risk...

Font Awesome Icons
View more

is free, fast, and customized just for you!

Already a member?

Sign In Now »