Generic Name and Formulations:
Acetylcysteine 100mg/mL, 200mg/mL; soln for inhalation; preservative-free.
Various generic manufacturers
Adjuvant therapy in patients with abnormal, viscid, or inspissated mucous secretions in such conditions as: chronic bronchopulmonary disease, acute bronchopulmonary disease, pulmonary complications of cystic fibrosis, tracheostomy care, pulmonary complications associated with surgery, use during anesthesia, post-traumatic chest conditions, atelectasis due to mucous obstruction, diagnostic bronchial studies.
See literature for administration of aerosol. Nebulization-face mask, mouth piece, tracheostomy: 1–10mL of 20% soln or 2–20mL of 10% soln every 2–6 hours; usual dose: 3–5mL of 20% soln or 6–10mL of 10% soln 3–4 times daily. Nebulization tent, croupette: individualize; requires very large volumes, occasionally as much as 300mL during a single treatment period; recommended dose is the volume of acetylcysteine (using 10% or 20%) that will maintain a very heavy mist for the desired period. Direct instillation: 1–2mL of 10% to 20% soln may be given as often as every hour. Tracheostomy: 1–2mL of 10% or 20% soln every 1–4 hours by instillation into the tracheostomy. Direct instillation into segment of bronchopulmonary tree: Under local anesthesia and direct vision, insert small plastic catheter into trachea; 2–5mL of 20% soln may be instilled by means of syringe connected to catheter. Percutaneous intrathecal catheter: 1–2mL of 20% soln or 2–4mL of 10% soln every 1–4 hours given by syringe attached to catheter. Diagnostic bronchograms: Two or three administrations of 1–2mL of 20% soln or 2–4mL of 10% soln should be given by nebulization or by instillation intratracheally, prior to procedure.
Increased volume of bronchial secretions may occur after administration, airway must be maintained open. Asthma; monitor for bronchospasm; discontinue if occurs. Pregnancy (Cat.B). Nursing mothers.
Do not mix with other drugs in nebulizer.
Stomatitis, GI upset, fever, rhinorrhea, drowsiness, clamminess, chest tightness, bronchoconstriction.
Formerly known under the brand name Mucomyst.
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